Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Validation of a guideline-based composite outcome assessment tool for asthma control. | Respiratory Research BioMed Central Research Validation of a guideline-based composite outcome assessment tool for asthma control Sally Spencer 1 Bhabita Mayer2 Kate L Bendall3 and Eric D Bateman4 Open Access Address 1Brunel University Uxbridge UK 2GlaxoSmithKline Research Development Greenford UK 3Giant Group PLC London UK and 4University of Cape Town Cape Town South Africa Email Sally Spencer - Bhabita Mayer - Kate L Bendall - katebendall@ Eric D Bateman - ebateman@ Corresponding author Published 21 March 2007 Respiratory Research 2007 8 26 doi 1465-9921 -8-26 Received 27 July 2006 Accepted 21 March 2007 This article is available from http content 8 1 26 2007 Spencer et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background A global definition of asthma control does not currently exist. The purpose of this study was to validate two new guideline-based composite measures of asthma control defined as totally controlled TC asthma and well controlled WC asthma. Methods We used data from 3416 patients randomised and treated in the multi-centre Gaining Optimal Asthma controL GOAL study. The criteria comprising the asthma control measures were based on Global Initiative for Asthma National Institutes of Health guidelines. This validation study examined the measurement properties of the asthma control measures using data from runin baseline 12 and 52 weeks. Forced expiratory volume in 1 second FEV1 and the Asthma Quality of Life Questionnaire AQLQ were used as the reference criteria in the validation analysis. Results Both measures had good discriminative ability showing significant differences in FEV1 .
