Báo cáo y học: " AIDS patients have increased surfactant protein D but normal mannose binding lectin levels in lung fluid"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " AIDS patients have increased surfactant protein D but normal mannose binding lectin levels in lung fluid. | Respiratory Research BioMed Central Research AIDS patients have increased surfactant protein D but normal mannose binding lectin levels in lung fluid Kondwani C Jambo1 Neil French2 Ed Zijlstra3 and Stephen B Gordon 4 Open Access Address 1Malawi-Liverpool-Wellcome Trust Clinical Research Programme Blantyre Malawi 2Wellcome Trust LEPRA Karonga Prevention Study London School of Hygiene and Tropical Medicine Chilumba Malawi 3Department of Medicine University of Malawi College of Medicine Blantyre Malawi and 4Liverpool School of Tropical Medicine Liverpool UK Email Kondwani C Jambo - kjambo@ Neil French - Ed Zijlstra - eezijlstra@ Stephen B Gordon - sbgordon@ Corresponding author Published 13 June 2007 Respiratory Research 2007 8 42 doi 1465-9921 -8-42 Received 21 February 2007 Accepted 13 June 2007 This article is available from http content 8 1 42 2007 Jambo et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Surfactant protein D SP-D and Mannose Binding Lectin MBL are collectins that have opsonic and immunoregulatory functions are found in lung fluid and interact with the human immunodeficiency virus HIV . We compared collectin levels in lung fluid and serum from HIV infected and normal subjects to determine if alterations in lung collectin levels were associated with HIV infection and might result in increased susceptibility to other pulmonary infections. Methods Blood and bronchoalveolar lavage samples were collected from 19 HIV-infected individuals and 17 HIV-uninfected individuals all with normal chest X ray at time of study. HIV

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