Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Control of mucosal virus infection by influenza nucleoprotein-specific CD8+ cytotoxic T lymphocytes. | Respiratory Research BioMed Central Research Control of mucosal virus infection by influenza nucleoprotein-specific CD8 cytotoxic T lymphocytes Innocent N Mbawuike Yongxin Zhang and Robert B Couch Open Access Address Viral Respiratory Pathogens Research Unit Departments of Molecular Virology and Microbiology Baylor College of Medicine Houston Texas 77030 UsA Email Innocent N Mbawuike - mbawuike@ Yongxin Zhang - yongxinz58@ Robert B Couch - rcouch@ Corresponding author Published 27 June 2007 Received 7 February 2007 Respiratory Research 2007 8 44 doi 1465-9921 -8-44 Accepted 27 June 2007 This article is available from http content 8 1 44 2007 Mbawuike et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background MHC class I-restricted CD8 cytotoxic T lymphocytes CTL are thought to play a major role in clearing virus and promoting recovery from influenza infection and disease. This has been demonstrated for clearance of influenza virus from the lungs of infected mice. However human influenza infection is primarily a respiratory mucosal infection involving the nasopharynx and tracheobronchial tree. The role of CD8 CTL directed toward the influenza nucleoprotein NP in defense against influenza virus infection at the respiratory mucosa was evaluated in two separate adoptive transfer experiments. Methods Influenza nucleoprotein NP -specific CD8 CTL were generated from splenocytes obtained from Balb c mice previously primed with influenza A Taiwan l 86 H1N1 infection or with influenza A PR 8 34 H1N1 -derived NP plasmid DNA vaccine followed by infection with A Hong Kong 68 .
