Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery. | Respiratory Research BioMed Central Research Open Access Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery Craig P Hersh 1 2 3 Dawn L DeMeo1 2 3 John J Reilly2 3 and Edwin K Silverman1 2 3 Address 1Channing Laboratory Department of Medicine Brigham and Women s Hospital Boston MA USA 2Division of Pulmonary and Critical Care Medicine Brigham and Women s Hospital Boston MA USA and 3Harvard Medical School Boston MA USA Email Craig P Hersh - Dawn L DeMeo - John J Reilly - jreilly@ Edwin K Silverman - Corresponding author Published 8 August 2007 Received 10 April 2007 Respiratory Research 2007 8 59 doi 1465-9921 -8-59 Accepted 8 August 2007 This article is available from http content 8 1 59 2007 Hersh et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In the National Emphysema Treatment Trial NETT marked variability in response to lung volume reduction surgery LVRS was observed. We sought to identify genetic differences which may explain some of this variability. Methods In 203 subjects from the NETT Genetics Ancillary Study four outcome measures were used to define response to LVRS at six months modified BODE index post-bronchodilator FEV1 maximum work achieved on a cardiopulmonary exercise test and University of California San Diego shortness of breath questionnaire. Sixty-four single nucleotide polymorphisms SNPs were genotyped in five genes previously shown to be associated with chronic obstructive pulmonary disease susceptibility exercise capacity or emphysema distribution. Results A SNP upstream from .
