Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Effect of hypoxia and Beraprost sodium on human pulmonary arterial smooth muscle cell proliferation: the role of p27kip1. | Respiratory Research BioMed Central Research Open Access Effect of hypoxia and Beraprost sodium on human pulmonary arterial smooth muscle cell proliferation the role of p27kipl Maiko Kadowaki 1 Shiro Mizuno 1 Yoshiki Demura1 Shingo Ameshima1 Isamu Miyamori1 and Takeshi Ishizaki 2 Address 1Third Department of Internal Medicine University of Fukui 23-3 Eiheiji-cho Matsuoka Yoshida-gun Fukui Japan and 2Department of Fundamental Nursing University of Fukui 23-3 Eiheiji-cho Matsuoka Yoshida-gun Fukui Japan Email Maiko Kadowaki - maik@ Shiro Mizuno - shirotan@ Yoshiki Demura - demura@ Shingo Ameshima - ame@ Isamu Miyamori - miyamori@ Takeshi Ishizaki - takeshi@ Corresponding author fEqual contributors Published I November 2007 Received 17 June 2007 __L- nn-7 J_ . in I I oz 1 At c nm I 0-7-7 Accepted 1 November 2007 Respiratory Research 2007 8 77 doi 1465-9921 -8-77 This article is available from http content 8 1 77 2007 Kadowaki et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Hypoxia induces the proliferation of pulmonary arterial smooth muscle cell PASMC in vivo and in vitro and prostacyclin analogues are thought to inhibit the growth of PASMC. Previous studies suggest that p27kip1 a kind of cyclin-dependent kinase inhibitor play an important role in the smooth muscle cell proliferation. However the mechanism of hypoxia and the subcellular interactions between p27kip1 and prostacyclin analogues in human pulmonary arterial smooth muscle cell HPASMC are not fully understood. Methods We investigated the role of p27kip1 in the ability of Beraprost sodium BPS a stable prostacyclin .
