Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke. | Respiratory Research BioMed Central Research Epithelial expression of TLR4 is modulated in COPD and by steroids salmeterol and cigarette smoke Ruth E MacRedmond 11 2 Catherine M Greene11 Delbert R Dorscheid2 Noel G McElvaney1 and Shane J O Neill1 Open Access Address Departments of Medicine Respiratory Research Royal College of Surgeons in Ireland Dublin Ireland and 2The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research Critical Care Group St. Paul s Hospital University of British Columbia Vancouver Canada Email Ruth E MacRedmond - rmacredmond@ Catherine M Greene - CMGreene@ Delbert R Dorscheid - ddorscheid@ Noel G McElvaney - ngmcelvaney@ Shane J O Neill - soneill@ Corresponding author fEqual contributors Published 22 November 2007 Respiratory Research 2007 8 84 doi 1465-9921 -8-84 Received 11 June 2007 Accepted 22 November 2007 This article is available from http content 8 1 84 2007 MacRedmond et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The toll-like receptors TLRs are a key component of host defense in the respiratory epithelium. Cigarette smoking is associated with increased susceptibility to infection while COPD is characterised by bacterial colonisation and infective exacerbations. We found reduced TLR4 gene expression in the nasal epithelium of smokers compared with non-smoking controls while TLR2 expression was unchanged. Severe COPD was associated with reduced TLR4 expression compared to less severe disease with good correlation between nasal and tracheal expression. We went on to examine the effect of potential modulators of TLR4 expression in respiratory epithelium pertinent to airways disease. Using
