Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Pioglitazone is as effective as dexamethasone in a cockroach allergen-induced murine model of asthma. | Respiratory Research BioMed Central Research Pioglitazone is as effective as dexamethasone in a cockroach allergen-induced murine model of asthma Venkata R Narala1 Rajesh Ranga1 Monica R Smith1 Aaron A Berlin2 Theodore J Standiford1 Nicholas W Lukacs2 and Raju C Reddy 1 Open Access Address Department of Internal Medicine Division of Pulmonary and Critical Care Medicine University of Michigan Medical Center Ann Arbor MI 48109-2200 USA and 2Department of Pathology University of Michigan Ann Arbor MI 48109 USA Email Venkata R Narala - narala@ Rajesh Ranga - rangara@ Monica R Smith - monsmith@ Aaron A Berlin - aaberlin@ Theodore J Standiford - tstandif@ Nicholas W Lukacs - nlukacs@ Raju C Reddy - rajuc@ Corresponding author Published 4 December 2007 Received 26 July 2007 Respiratory Research 2007 8 90 doi 1465-9921 -8-90 Accepted 4 December 2007 This article is available from http content 8 1 90 2007 Narala et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background While glucocorticoids are currently the most effective therapy for asthma associated side effects limit enthusiasm for their use. Peroxisome proliferator-activated receptor-Y PPAR-y activators include the synthetic thiazolidinediones TZDs which exhibit antiinflammatory effects that suggest usefulness in diseases such as asthma. How the ability of TZDs to modulate the asthmatic response compares to that of glucocorticoids remains unclear however because these two nuclear receptor agonists have never been studied concurrently. Additionally effects of PPAR-y agonists have .
