Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " IL13 gene polymorphisms modify the effect of exposure to tobacco smoke on persistent wheeze and asthma in childhood, a longitudinal study. | Respiratory Research BioMed Central Research ILI3 gene polymorphisms modify the effect of exposure to tobacco smoke on persistent wheeze and asthma in childhood a longitudinal study Alireza Sadeghnejad 1 Wilfried Karmaus 2 S Hasan Arshad3 4 Ramesh Kurukulaaratchy3 4 Marianne Huebner5 and Susan Ewart6 Address 1Center for Human Genomics Wake Forest University School of Medicine Winston-Salem North Carolina USA 2Department of Epidemiology and Biostatistics University of South Carolina Columbia South Carolina USA 3The David Hide Asthma Allergy Research Centre St. Mary s Hospital Isle of Wight UK 4IIR Research Division School of Medicine University of Southampton Southampton UK 5Department of Statistics and Probability Michigan State University East Lansing Michigan USA and 6Department of Large Animal Clinical Sciences Michigan State University East Lansing Michigan USA Email Alireza Sadeghnejad - asadeghn@ Wilfried Karmaus - karmaus@ S Hasan Arshad - Ramesh Kurukulaaratchy - ramesh@ Marianne Huebner - huebner@ Susan Ewart - ewart@ Corresponding authors Open Access Published 10 January 2008 Received 29 May 2007 Respiratory Research 2008 9 2 doi l465-992l-9-2 Accepted I0 January 2008 This article is available from http content 9 l 2 2008 Sadeghnejad et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Tobacco smoke and genetic susceptibility are risk factors for asthma and wheezing. The aim of this study was to investigate whether there is a combined effect of interleukin-l3 gene ILI3 polymorphisms and tobacco smoke on persistent childhood wheezing and asthma. Methods In the Isle of Wight birth cohort .
