Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study. | Respiratory Research BioMed Central Open Access Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D SP-D levels a cross-sectional study Michael W Sims1 Ruth M Tal-Singer2 Sonja Kierstein1 Ali I Musani1 Michael F Beers1 Reynold A Panettieri11 and Angela Haczku 11 Address Department of Medicine University of Pennsylvania Philadelphia PA USA and 2COPD Biology GlaxoSmithKline King of Prussia PA USA Email Michael W Sims - Ruth M Tal-Singer - Sonja Kierstein - skierstein@ Ali I Musani - Michael F Beers - mfbeers@ Reynold A Panettieri - rap@ Angela Haczku - haczku@ Corresponding author fEqual contributors Published 28 January 2008 Received 6 August 2007 Respiratory Research 2008 9 13 doi 1465-9921-9-13 Accepted 28 Januaty 2008 This article is available from http content 9 1 13 2008 Sims et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Surfactant protein D SP-D an innate immune molecule plays an important protective role during airway inflammation. Deficiency of this molecule induces emphysematous changes in murine lungs but its significance in human COPD remains unclear. Methods We collected bronchoalveolar lavage fluid from 20 subjects with varying degrees of COPD 8 former smokers and 12 current smokers and 15 asymptomatic healthy control subjects 5 never smokers 3 remote former smokers and 7 current smokers . All subjects underwent a complete medical history and pulmonary function testing. SP-D was measured by Enzyme-Linked ImmunoSorbent Assay. Statistical analysis was performed using nonparametric .
