Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Effects of intranasal TNFα on granulocyte recruitment and activity in healthy subjects and patients with allergic rhinitis. | Respiratory Research BioMed Central Research Effects of intranasal TNFa on granulocyte recruitment and activity in healthy subjects and patients with allergic rhinitis Henrik Widegren 1 Jonas Erjefalt2 Magnus Korsgren3 Morgan Andersson1 and Lennart Greiff1 Address Department of Otorhinolaryngology Head Neck Surgery Lund University Hospital Lund Sweden 2Department of Experimental Medical Sciences Lund University Lund Sweden and 3Department of Clinical Pharmacology Lund University Hospital Lund Sweden Email Henrik Widegren - Jonas Erjefalt - Magnus Korsgren - Morgan Andersson - Lennart Greiff - Corresponding author Open Access Published 30 January 2008 Received 6 November 2007 Respiratory Research 2008 9 15 doi 1465-9921-9-15 Accepted 30 Januaty 2008 This article is available from http content 9 1 15 2008 Widegren et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background TNFa may contribute to the pathophysiology of airway inflammation. For example we have recently shown that nasal administration of TNFa produces late phase co-appearance of granulocyte and plasma exudation markers on the mucosal surface. The objective of the present study was to examine indices of granulocyte presence and activity in response to intranasal TNFa challenge. Methods Healthy subjects and patients with allergic rhinitis examined out of season were subjected to nasal challenge with TNFa 10 pg in a sham-controlled and crossover design. Nasal lavages were carried out prior to and 24 hours post
