Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Regulation of the cd38 promoter in human airway smooth muscle cells by TNF-α and dexamethasone. | Respiratory Research BioMed Central Research Open Access Regulation of the cd38 promoter in human airway smooth muscle cells by TNF-a and dexamethasone Krishnaswamy G Tirnmurugaan41 Bit Na Kang41 Reynold A Panettieri2 Douglas N Foster3 Timothy F Walseth4 and Mathur S Kannan 1 5 Address Department of Veterinary and Biomedical Sciences College of Veterinary Medicine University of Minnesota St. Paul MN USA 2Department of Medicine University of Pennsylvania Philadelphia PA USA 3Department of Animal Science University of Minnesota St. Paul MN USA 4Department of Pharmacology College of Medicine University of Minnesota Minneapolis MN USA and 5Department of Pediatrics College of Medicine University of Minnesota Minneapolis MN USA Email Krishnaswamy G Tirumurugaan - drthiru20@ Bit Na Kang - kang0194@ Reynold A Panettieri - rap@ Douglas N Foster - foste001@ Timothy F Walseth - walse001@ MathurS Kannan - kanna001@ Corresponding author tEqual contributors Published 14 March 2008 Received 5 December 2007 Respiratory Research 2008 9 26 doi l465-992l-9-26 Accepted I4 March 2008 This article is available from http content 9 l 26 2008 Tirumurugaan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background CD38 is expressed in human airway smooth muscle HASM cells regulates intracellular calcium and its expression is augmented by tumor necrosis factor alpha TNF-a . CD38 has a role in airway hyperresponsiveness a hallmark of asthma since deficient mice develop attenuated airway hyperresponsiveness compared to wild-type mice following intranasal challenges with cytokines such as IL-13 and TNF-a. Regulation of CD38 expression in HASM cells .
