Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Open Access Changes in elastin, elastin binding protein and versican in alveoli in chronic obstructive pulmonary disease. | Respiratory Research BioMed Central Research Changes in elastin elastin binding protein and versican in alveoli in chronic obstructive pulmonary disease Mervyn J Merrilees 1 Pamela ST Ching1 Brent Beaumont1 Aleksander Hinek2 Thomas N Wight3 and Peter N Black4 Address Department of Anatomy with Radiology Faculty of Medical and Health Sciences The University of Auckland Auckland New Zealand 2Cardiovascular Research Program Hospital for Sick Children Toronto Canada 3Hope Heart Program at Benaroya Research Institute Virginia Mason Seattle WA USA and 4Department of Pharmacology Clinical Pharmacology Faculty of Medical and Health Sciences The University of Auckland Auckland New Zealand Email Mervyn J Merrilees - Pamela ST Ching - pamela1c@ Brent Beaumont - brentbeaumont@ Aleksander Hinek - Thomas N Wight - twight@ Peter N Black - Corresponding author Open Access Published 18 May 2008 Received 18 February 2008 Respiratory Research 2008 9 41 doi 1465-9921 -9-41 Accepted 18 May 2008 This article is available from http content 9 1 41 2008 Merrilees et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background COPD is characterised by loss of alveolar elastic fibers and by lack of effective repair. Elastic fibers are assembled at cell surfaces by elastin binding protein EBP a molecular chaperone whose function can be reversibility inhibited by chondroitin sulphate of matrix proteoglycans such as versican. This study aimed to determine if alveoli of patients with mild to moderate COPD contained increased amounts of versican and a corresponding decrease in EBP and if these .
