Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Could a defective epithelial sodium channel lead to bronchiectasis. | Respiratory Research BioMed Central Research Could a defective epithelial sodium channel lead to bronchiectasis Isabelle Fajac 1 2 Marion Viel3 Sébastien Sublemontier3 Dominique Hubert2 4 and Thierry Bienvenu3 5 6 Open Access Address Service d Explorations Fonctionnelles AP-HP Hôpital Cochin Paris France 2Université Paris Descartes UPRES EA 2511 Faculté de Médecine Paris France 3Laboratoire de Biochimie et Génétique Moléculaires AP-HP Hôpital Cochin Paris France 4Service de Pneumologie AP-HP Hôpital Cochin Paris France 5Université Paris Descartes Institut Cochin CNRS UMR 8104 Paris France and 6Inserm U567 Paris France Email Isabelle Fajac - ifajac@ Marion Viel - Sébastien Sublemontier - sebastien_sublemontier@ Dominique Hubert - Thierry Bienvenu - bienvenu@ Corresponding author Published 28 May 2008 Respiratory Research 2008 9 46 doi 1465-9921 -9-46 Received 25 March 2008 Accepted 28 May 2008 This article is available from http content 9 1 46 2008 Fajac et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Bronchiectasis is defined as a permanent dilation of the airways arising from chronic bronchial inflammation infection. In 50 of cases no etiology can be identified. Recently the role of the epithelial sodium channel ENaC has been pointed out in the pathophysiology of cystic fibrosis a disease due to mutations in the CFTR gene and causing bronchiectasis in the airways. Moreover it was found that transgenic mice overexpressing ENaCfl present cystic fibrosis-like lung disease symptoms. Our aim was to evaluate if a defective ENaC protein could be involved in the development of
