Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: A novel preclinical model for rheumatoid arthritis research. | Petersen and Yu Arthritis Research Therapy 2010 12 148 http content 12 6 148 i artMtipi EDITORIAL A novel preclinical model for rheumatoid arthritis research Frank Petersen and Xinhua Yu See related research by Vierboom etal. http content 12 5 R200 Abstract Based on increasing knowledge on the pathogenesis of rheumatoid arthritis RA more and more potential therapeutics have been developed. To evaluate their therapeutic efficacy safety and toxicity appropriate animal models are required. Although rodent models of RA have been extensively used for preclinical evaluation the differences between rodents and humans limit their usability for some species-specific therapeutics. Therefore autoimmune arthritis developed in a non-human primate with essential hallmarks of RA will be an alternative model for preclinical studies. In the previous issue Vierboom and colleagues 1 report on a novel animal model of rheumatoid arthritis RA induced in common marmosets by immunization with bovine chicken type II collagen CII . As a cartilagespecific protein CII is constitutively expressed in the synovial joint which is the tissue predominantly affected in RA. CII has been suspected to be an important autoantigen and was used to establish several animal models of RA. In 1977 the first collagen-induced arthritis CIA model was established in rats by immunization with CII 2 . Subsequently this CIA model was reproduced in mouse and monkey in 1980 and 1986 respectively 3 4 . The essential hallmarks of CIA - for example autoimmune response-mediated synovitis and subsequent erosion in cartilage and bone - resemble RA which makes it the most widely used animal model for RA research. The rodent model of CIA has been extensively used for investigation of the pathogenesis of the disease and the identification of novel therapeutics and for preclinical studies in RA research. Due to a large evolutionary Correspondence xinhuayu@ Department of
