Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Anticitrullinated protein antibody (ACPA) in rheumatoid arthritis: influence of an interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione s-transferase in a cross-sectional study. | Mikuls et al. Arthritis Research Therapy 2010 12 R213 http content 12 6 R213 RESEARCH ARTICLE Open Access Anticitrullinated protein antibody ACPA in rheumatoid arthritis influence of an interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione s-transferase in a cross-sectional study Ted R Mikuls1 Karen A Gould2 Kimberly K Bynoté2 Fang Yu3 Tricia D LeVan4 Geoffrey M Thiele1 Kaleb D Michaud1 James R O Dell1 Andreas M Reimold5 Roderick Hooker5 Liron Caplan6 Dannette S Johnson7 8 8 9 10 11 12 Gail Kerr J Steuart Richards Grant W Cannon Lindsey A Criswell Janelle A Noble S Louis Bridges Jr Laura Hughes12 Peter KGregersen13 Abstract Introduction A deletion polymorphism in glutathione S-transferase Mu-1 GSTM1-null has previously been implicated to play a role in rheumatoid arthritis RA risk and progression although no prior investigations have examined its associations with anticitrullinated protein antibody ACPA positivity. The purpose of this study was to examine the associations of GSTMl-null with ACPA positivity in RA and to assess for evidence of interaction between GSTM1 and HLA-DRB1 shared epitope SE . Methods Associations of GSTM1-null with ACPA positivity were examined separately in two RA cohorts the Veterans Affairs Rheumatoid Arthritis VARA registry n 703 and the Study of New-Onset RA SONORA n 610 . Interactions were examined by calculating an attributable proportion AP due to interaction. Results A majority of patients in the VARA registry 76 and SONORA 69 were positive for ACPA with a similar frequency of GSTM1-null 53 and 52 respectively and HLA-DRB1 SE positivity 76 and 71 respectively . The parameter of patients who had ever smoked was more common in the VARA registry 80 than in SONORA 65 . GSTM1-null was significantly associated with ACPA positivity in the VARA registry odds ratio OR 95 confidence interval CI to but not in SONORA OR 95 CI to . There were significant .
