Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Epidemiology of gout. | Roddy and Doherty Arthritis Research Therapy 2010 12 223 http content 12 6 223 REVIEW L_ Epidemiology of gout Edward Roddy 1 and Michael Doherty2 Abstract Gout is the most prevalent form of inflammatory arthropathy. Several studies suggest that its prevalence and incidence have risen in recent decades. Numerous risk factors for the development of gout have been established including hyperuricaemia genetic factors dietary factors alcohol consumption metabolic syndrome hypertension obesity diuretic use and chronic renal disease. Osteoarthritis predisposes to local crystal deposition. Gout appears to be an independent risk factor for all-cause mortality and cardiovascular mortality and morbidity additional to the risk conferred by its association with traditional cardiovascular risk factors. Introduction Gout is the most prevalent form of inflammatory arthritis and is associated with impaired quality of life 1-3 . Elevation of serum uric acid SUA levels or hyperuri-caemia is an essential prerequisite for the development of gout. As SUA levels rise and the physiological saturation threshold for uric acid is exceeded in body fluids the formation and deposition of monosodium urate MSU crystals occurs in and around joints. Clinical manifestations of MSU crystal deposition include acute attacks of severe pain and inflammation affecting peripheral joints most commonly the first metatarsophalangeal MTP joint chronic joint damage and tophaceous deposits of MSU crystals in the joints and skin. Recent epidemiological studies have described trends in the prevalence and incidence of gout and have increased our understanding of risk factors for its development and the implications of co-morbid disease on mortality and cardiovascular morbidity. Correspondence 1Arthritis Research UK Primary Care Centre Primary Care Sciences Keele University Staffordshire ST5 5BG UK Full list of author information is available at the end of the .
