Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Surprising negative association between IgG1 allotype disparity and anti-adalimumab formation: a cohort study. | Bartelds et al. Arthritis Research Therapy 2010 12 R221 http content 12 6 R221 RESEARCH ARTICLE Open Access Surprising negative association between IgG1 allotype disparity and anti-adalimumab formation a cohort study 12 13 2 4 Geertje M Bartelds Els de Groot Michael T Nurmohamed 1 Margreet HL Hart Peter H van Eede 5 6 13 5 2 Carla A Wijbrandts Jakob BA Crusius Ben AC Dijkmans Paul Peter Tak Lucien Aarden Gerrit J Wolbink Abstract Introduction The human monoclonal antibody adalimumab is known to induce an anti-globulin response in some adalimumab-treated patients. Antibodies against adalimumab AAA are associated with non-response to treatment. Immunoglobulins such as adalimumab carry allotypes which represent slight differences in the amino acid sequences of the constant chains of an IgG molecule. Immunoglobulins with particular IgG Gm allotypes are racially distributed and could be immunogenic for individuals who do not express these allotypes. Therefore we investigated whether a mismatch in IgG allotypes between adalimumab and IgG in adalimumab-treated patients is associated with the development of AAA. Methods This cohort study consisted of 250 adalimumab-treated rheumatoid arthritis RA patients. IgG allotypes were determined for adalimumab and for all patients. Anti-idiotype antibodies against adalimumab were measured with a regular radio immunoassay RIA and a newly developed bridging enzyme linked immunosorbent assay ELISA was used to measure anti-allotype antibodies against adalimumab. The association between AAA and the G1m3 and the G1m17 allotypes was determined. For differences between groups we used the independent or paired samples t-test Mann-Whitney test or Chi square Fisher s exact test as appropriate. To investigate the influence of confounders on the presence or absence of AAA a multiple logistic regression-analysis was used. Results Adalimumab carries the G1m17 allotype. No anti-allotype antibodies against adalimumab were
