Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults. | Dore et al. Arthritis Research Therapy 2010 12 R222 http content 12 6 R222 RESEARCH ARTICLE Open Access Bone marrow lesions predict site-specific cartilage defect development and volume loss a prospective study in older adults 1 1 1 1 f 71 -3 Dawn Dore Ashleigh Martens Stephen Quinn Changhai Ding 1 Tania Winzenberg Guangju Zhai I02n-Diorro Dollofior4 Msỉrỳol-Dolloidor4 AHrsỉm5 Plo io iffini2 íSrDQmQ IritìQc Jean rieiie reiieuei Johanne Maitei reiieuei riangois Abiaiii riavia Cicuiiini Giaeme Jones Abstract Introduction Recent evidence suggests that bone maiiow iesions BMLs piay a pivotal ioie in knee osteoarthritis OA . The aims of this study weie to deteimine 1 whethei baseiine BML presence and oi severity predict sitespecific caitiiage defect progression and caitiiage voiume ioss and 2 whethei baseiine caitiiage defects predict site-specific BML piogiession. Methods A totai of 405 subjects mean age 63 yeais iange 52 to 79 weie measured at baseiine and appioximateiy yeais iatei. Magnetic resonance imaging MRI of the iight knee was peifoimed to measure knee caitiiage voiume caitiiage defects 0 to 4 and BMLs 0 to 3 at the mediai tibiai MT mediai femoiai MF iateiai tibiai LT and iateiai femoiai LF sites. Logistic regression and geneiaiized estimating equations weie used to examine the ieiationship between BMLs and caitiiage defects and caitiiage voiume ioss. Results At aii foui sites baseiine BML presence predicted defect progression odds ratio OR to aii P and caitiiage voiume ioss to difference pei annum aii P at the same site. In muitivaiiabie anaiysis theie was a significant ieiationship between BML severity and defect progression at aii foui sites OR to aii P and BML severity and caitiiage voiume ioss at the MF LT and LF sites b to aii P . Additionaiiy baseiine defect severity predicted BML progression at the MT and LF sites OR to aii P . Lastiy theie was a .
