Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis. | Larsson et al. Arthritis Research Therapy 2010 12 R230 http content 12 6 R230 RESEARCH ARTICLE Open Access Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis Staffan Larsson1 Martin Englund1 2 André Struglics1 L Stefan Lohmander1 Abstract Introduction Aggrecanase cleavage at the 392Glu-393Ala bond in the interglobular domain IGD of aggrecan releasing N-terminal 393ARGS fragments is an early key event in arthritis and joint injuries. We determined whether synovial fluid SF levels of ARGS-aggrecan distinguish subjects with progressive radiographic knee osteoarthritis ROA from those with stable or no ROA. Methods We studied 141 subjects who at examination A had been given meniscectomies an average of 18 years earlier range 15 to 22 years . Seventeen individuals without surgery and without known injury to the menisci or cruciate ligaments were used as references. At examinations A and B with a mean follow-up time of years we obtained SF and standing tibiofemoral and skyline patellofemoral radiographs. SF ARGS-aggrecan was measured with an electrochemiluminescence immunoassay and we graded radiographs according to the OARSI atlas. The association between SF ARGS levels at examination A and progression of radiographic features of knee OA between examinations A and B was assessed by using logistic regression adjusted for age gender body mass index and time between examinations and stratified by ROA status at examination A. Results We found a weak negative association between SF ARGS concentrations and loss of joint space the likelihood of progression of radiographic joint space narrowing decreased times per picomole per milliliter increase in ARGS odds ratio OR 95 confidence interval CI to . In subjects with and without preexisting ROA at examination A the association was OR to and to respectively. Average levels of SF ARGS 18
