Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Contemporary epidemiology of gout in the UK general population. | Cea Soriano et al. Arthritis Research Therapy 2011 13 R39 http content 13 2 R39 RESEARCH ARTICLE Open Access Contemporary epidemiology of gout in the UK general population Lucia Cea Soriano1 Dietrich Rothenbacher2 Hyon K Choi3 and Luis A García Rodríguez1 Abstract Introduction The objective of this study was to investigate the contemporary incidence of gout examine potential risk factors and evaluate specific gout treatment patterns in the general population. Methods Using the health improvement network THIN UK primary care database we estimated the incidence of gout based on 24 768 newly diagnosed gout patients among a cohort of 1 775 505 individuals aged 20 to 89 years between 2000 and 2007. We evaluated potential risk factors for incident gout in a nested case-control study with 50 000 controls frequency-matched by age sex and calendar time. We calculated odds ratios OR by means of unconditional logistic regression adjusting for demographic variables lifestyle variables relevant medical conditions and drug exposures. Results The incidence of gout per 1 000 person-years was in men and in women and increased with age. Conventional risk factors were significantly and strongly associated with the risk of gout with multivariate ORs of 95 confidence interval CI for excessive alcohol intake that is more than 42 units per week 95 CI to for obesity body mass index 30 kg m2 95 CI to for chronic renal impairment and 95 CI to for current diuretic use. For other medical conditions the multivariate OR were 95 CI to for heart failure 95 CI to for hypertriglyceridemia and 95 CI to for psoriasis. Use of cyclosporine was associated with an OR of 95 CI to . Among gout-specific therapies allopurinol was the most frequently used with a one-year cumulative incidence of 28 in a cohort of incident gout diagnosed from 2000 to 2001. Use of .
