Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Platelet-derived growth factor receptor-b and epidermal growth factor receptor in pulmonary vasculature of systemic sclerosis-associated pulmonary arterial hypertension versus idiopathic pulmonary arterial hypertension and pulmonary veno-occlusive disease: a case-control study. | Overbeek et al. Arthritis Research Therapy 2011 13 R61 http content 13 2 R61 RESEARCH ARTICLE Open Access Platelet-derived growth factor receptor-p and epidermal growth factor receptor in pulmonary vasculature of systemic sclerosis-associated pulmonary arterial hypertension versus idiopathic pulmonary arterial hypertension and pulmonary veno-occlusive disease a case-control study 1 1 2 3 1 Maria J Overbeek Anco Boonstra Alexandre E Voskuyl Madelon C Vonk Anton Vonk-Noordegraaf DA n Rorlzol4 A nlfor I KAnni5 Ron A rìiíl meỉnc2 I irone c I InnHorneỉ5 RmKort- R Qmit 1 unrl Maiia PA van Beikel vvoltei J iviooi Ben AC Dijkmans Lauiens S nondema Egbeit F Smit and Katrien Grunberg5 Abstract Introduction Systemic sclerosis SSc complicated by pulmonary arterial hypertension PAH carries a poor prognosis despite pulmonary vascular dilating therapy. Platelet-derived growth factor receptor-p PDGFR-p and epidermal growth factor receptor EGFR are potential therapeutic targets for PAH because of their proliferative effects on vessel remodelling. To explore their role in SScPAH we compared PDGFR- and EGFR-mmunoreactivity in lung tissue specimens from SScPAH. We compared staining patterns with idiopathic PAH IPAH and pulmonary veno-occlusive disease PVOD as SScPAH vasculopathy differs from IPAH and sometimes displays features of PVOD. Immunoreactivity patterns of phosphorylated PDGFR-p pPDGFR-p and the ligand PDGF-B were evaluated to provide more insight into the patterns of PDGFR-b activation. Methods Lung tissue specimens from five SScPAH nine IPAH six PVOD patients and five controls were examined. Immunoreactivity was scored for presence distribution and intensity. Results All SScPAH and three of nine IPAH cases P showed PDGFR-p-immunoreactivity in small vessels arterioles venules of five SScPAH vs. two of nine IPAH cases P showed venous immunoreactivity. In small vessels intensity was stronger in SScPAH vs. IPAH. No differences were found between
