Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Mucociliary and long-term particle clearance in airways of patients with immotile cilia. | Respiratory Research BioMed Central Research Open Access Mucociliary and long-term particle clearance in airways of patients with immotile cilia Winfried Moller 1 Karl HăuEinger2 Loms Ziegler-Heitbrock2 3 and Joachim Heyder1 Address 1Institute for Inhalation Biology and Clinical Research Group Inflammatory Lung Diseases GSF - National Research Centre for Environment and Health Robert Koch Allee 29 D-82131 Gauting-Munich Germany 2Department for Respiratory Medicine Asklepios Hospital Munich-Gauting Robert Koch Allee 2 D-82131 Gauting-Munich Germany and 3Department of Infection Immunity and Inflammation University of Leicester Medical Sciences Building Leicester LE1 9HN UK Email Winfried Moller - moeller@ Karl HăuKinger - Loms Ziegler-Heitbrock - ziegler-heitbrock@ Joachim Heyder - Corresponding author Published 19 January 2006 Received 26 September 2005 Respiratory Research 2006 7 10 doi l465-992l-7-l0 Accepted 19 January 2006 This article is available from http content 7 l l0 2006 Moller et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Spherical monodisperse ferromagnetic iron oxide particles of pm geometric and pm aerodynamic diameter were inhaled by seven patients with primary ciliary dyskinesia PCD using the shallow bolus technique and compared to l3 healthy non-smokers NS from a previous study. The bolus penetration front depth was limiting to the phasel dead space volume. In PCD patients deposition was 58 -8 after 8 s breath holding time. Particle retention was measured by the magnetopneumographic method over a period of nine months. Particle clearance from the airways showed a fast and a slow phase. In
