Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Wnt signalling in lung development and diseases. | Respiratory Research BioMed Central Review Wnt signalling in lung development and diseases Judit E Pongracz 1 2 and Robert A Stockley3 Open Access Address Department of Immunology and Biotechnology University of Pécs Pécs Hungary institute for Biomedical Research University of Birmingham Birmingham UK and 3Department of Medicine University of Birmingham Birmingham UK Email Judit E Pongracz - Robert A Stockley - Corresponding author Published 26 January 2006 Received 05 October 2005 Respiratory Research 2006 7 15 doi 1465-9921-7-15 Accepted 26 Januaty 2006 This article is available from http content 7 1 15 2006 Pongracz and Stockley licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ There are several signalling pathways involved in lung organogenesis including Notch TGFP BMP Sonic hedgehog Shh FGF EGF and Wnt. Despite the widely acknowledged significance of Wnt signalling in embryonic lung development the role of different Wnt pathways in lung pathologies has been slow to emerge. In this review we will present a synopsis of current Wnt research with particular attention paid to the role of Wnt signals in lung development and in pulmonary diseases. Overview of Wnt signalling The Wnt family of19 secreted glycoproteins control a variety of developmental processes including cell fate specification proliferation polarity and migration. Consequently mis-regulation of Wnt signalling during embryonic development cause developmental defects while defective Wnt signalling in adult tissue results in the development of various diseases 1 . As Wnt-s have a diverse role in .
