Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-β signaling in lung fibroblasts. | Respiratory Research BioMed Central Research Open Access EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-p signaling in lung fibroblasts Ying Ji Li1 2 Arata Azuma 1 Jiro Usuki1 Shinji Abe1 Kuniko Matsuda1 Toshiaki Sunazuka4 Takako Shimizu2 Yukiyo Hirata2 Hirofumi Inagaki2 Tomoyuki Kawada2 Satoru Takahashi3 Shoji Kudoh1 and Satoshi Omura4 Address 1Fourth Department of Internal Medicine Nippon Medical School Tokyo JAPAN 2Department of Hygiene and Public Health Nippon Medical School Tokyo JAPAN institute of Basic Medical Sciences University of Tsukuba Ibaragi JAPAN and 4Kitasato Institute for Life Sciences Kitasato University Tokyo JAPAN Email Ying Ji Li - lyj@ Arata Azuma - a-azuma@ Jiro Usuki - usukij@ Shinji Abe - sabe@ Kuniko Matsuda - kuniko-m@ Toshiaki Sunazuka - sunazuka@ Takako Shimizu - takako-s@ Yukiyo Hirata - yuki-hir@ Hirofumi Inagaki - hrfmi@ Tomoyuki Kawada - kawada@ Satoru Takahashi - satoruta@ Shoji Kudoh - kuntonjp@ Satoshi Omura- omura-s@ Corresponding author Published 27 January 2006 Received 04 August 2005 Respiratory Research2006 7 16 doi l465-992l-7-l6 Accepted 27 January 2006 This article is available from http content 7 l l6 2006Li et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Fourteen-membered ring macrolides have been effective in reducing chronic airway inflammation and also preventing lung injury and fibrosis in bleomycin-challenged mice via anti-inflammatory effects. EM703 is a new derivative of erythromycin EM without the bactericidal effects. We investigated .
