Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Epigenetics and airways disease. | Respiratory Research BioMed Central Review Epigenetics and airways disease Ian M Adcock Paul Ford Kazuhiro Ito and P J Barnes Open Access Address Airways Disease Section National Heart and Lung Institute Imperial College London UK Email Ian M Adcock - Paul Ford - Kazuhiro Ito - P J Barnes - Corresponding author Published 06 February 2006 Received 07 November 2005 Respiratory Research 2006 7 21 doi 1465-9921-7-21 Accepted 06 February 2006 This article is available from http content 7 1 21 2006 Adcock et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Epigenetics is the term used to describe heritable changes in gene expression that are not coded in the DNA sequence itself but by post-translational modifications in DNA and histone proteins. These modifications include histone acetylation methylation ubiquitination sumoylation and phosphorylation. Epigenetic regulation is not only critical for generating diversity of cell types during mammalian development but it is also important for maintaining the stability and integrity of the expression profiles of different cell types. Until recently the study of human disease has focused on genetic mechanisms rather than on non-coding events. However it is becoming increasingly clear that disruption of epigenetic processes can lead to several major pathologies including cancer syndromes involving chromosomal instabilities and mental retardation. Furthermore the expression and activity of enzymes that regulate these epigenetic modifications have been reported to be abnormal in the airways of patients with respiratory disease. The development of new .
