Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Prolonged ozone exposure in an allergic airway disease model: Adaptation of airway responsiveness and airway remodeling. | Respiratory Research BioMed Central Research Open Access Prolonged ozone exposure in an allergic airway disease model Adaptation of airway responsiveness and airway remodeling An-Soo Jang 3 Inseon-S Choi1 Jae-Hyuk Lee2 Chang-Soo Park2 and Choon-Sik Park3 Address Department of Internal Medicine Chonnam National University Medical School Gwangju Republic of Korea 2Pathology Chonnam National University Medical School Gwangju Republic of Korea and 3Department of Internal Medicine Soonchunhyang University Hospital Bucheon Gwangju Republic of Korea Email An-Soo Jang - jas877@ Inseon-S Choi - ischoi@ Jae-Hyuk Lee - jhlee@ Chang-Soo Park - cspark@ Choon-Sik Park - mdcspark@ Corresponding author Published 13 February 2006 Received 30 September 2005 Respiratory Research 2006 7 24 doi 1465-9921 -7-24 Accepted 13 February 2006 This article is available from http content 7 1 24 2006 Jang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Short-term exposure to high concentrations of ozone has been shown to increase airway hyper-responsiveness AHR . Because the changes in AHR and airway inflammation and structure after chronic ozone exposure need to be determined the goal of this study was to investigate these effects in a murine model of allergic airway disease. Methods We exposed BALB c mice to 2 ppm ozone for 4 8 and 12 weeks. We measured the enhanced pause Penh to methacholine and performed cell differentials in bronchoalveolar lavage fluid. We quantified the levels of IL-4 and IFN-Y in the supernatants of the bronchoalveolar lavage fluids using enzyme immunoassays and examined the airway architecture under light and
