Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Alterations in vasodilator-stimulated phosphoprotein (VASP) phosphorylation: associations with asthmatic phenotype, airway inflammation and β2-agonist use. | Respiratory Research BioMed Central Research Open Access Alterations in vasodilator-stimulated phosphoprotein VASP phosphorylation associations with asthmatic phenotype airway inflammation and P2-agonist use Annette T Hastie 1 Min Wu1 Gayle C Foster1 Gregory A Hawkins1 Vikas Batra2 Katherine A Rybinski2 Rosemary Cirelli2 James G Zangrilli2 and Stephen P Peters1 Address Department of Internal Medicine Center for Human Genomics Wake Forest University School of Medicine Winston-Salem NC USA and 2Department of Medicine Thomas Jefferson University Philadelphia PA USA Email Annette T Hastie - ahastie@ Min Wu - mwu@ Gayle C Foster - gcfoster@ Gregory A Hawkins - ghawkins@ Vikas Batra - batra72@ Katherine A Rybinski - kathyrybinski@ Rosemary Cirelli - lpcc2002@ James G Zangrilli - Stephen P Peters - sppeters@ Corresponding author Published 15 February 2006 Received 02 November 2005 Respiratory Research 2006 7 25 doi 1465-9921 -7-25 Accepted I5 February 2006 This article is available from http content 7 1 25 2006 Hastie et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Vasodilator-stimulated phosphoprotein VASP mediates focal adhesion actin filament binding and polymerization in a variety of cells thereby inhibiting cell movement. Phosphorylation of VASP via cAMP and cGMP dependent protein kinases releases this brake on cell motility. Thus phosphorylation of VASP may be necessary for epithelial cell repair of damage from allergen-induced inflammation. Two hypotheses were examined 1 injury from segmental allergen challenge increases VASP phosphorylation in airway .
