Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Antimicrobial proteins and polypeptides in pulmonary innate defence. | Respiratory Research BioMed Central Review Open Access Antimicrobial proteins and polypeptides in pulmonary innate defence Mark P Rogan Patrick Geraghty Catherine M Greene Shane J O Neill Clifford C Taggart and Noel G McElvaney Address Pulmonary Research Division Royal College of Surgeons in Ireland Beaumont Hospital Dublin Ireland Email Mark P Rogan - mrogan@ Patrick Geraghty - patgeraghty@ Catherine M Greene - cmgreene@ Shane J O Neill - shaneoneill@ Clifford C Taggart - ctaggart@ Noel G McElvaney - gmcelvaney@ Corresponding author Published 17 February 2006 Received 22 November 2005 Respiratory Research 2006 7 29 doi 1465-9921 -7-29 Accepted I7 February 2006 This article is available from http content 7 1 29 2006 Rogan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Inspired air contains a myriad of potential pathogens pollutants and inflammatory stimuli. In the normal lung these pathogens are rarely problematic. This is because the epithelial lining fluid in the lung is rich in many innate immunity proteins and peptides that provide a powerful anti-microbial screen. These defensive proteins have anti-bacterial anti- viral and in some cases even anti-fungal properties. Their antimicrobial effects are as diverse as inhibition of biofilm formation and prevention of viral replication. The innate immunity proteins and peptides also play key immunomodulatory roles. They are involved in many key processes such as opsonisation facilitating phagocytosis of bacteria and viruses by macrophages and monocytes. They act as important mediators in inflammatory pathways and are capable of binding bacterial endotoxins and CPG motifs. They can .
