Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Chronic Obstructive Pulmonary Disease, inflammation and co-morbidity – a common inflammatory phenotype. | Respiratory Research BioMed Central Commentary Open Access Chronic Obstructive Pulmonary Disease inflammation and co-morbidity - a common inflammatory phenotype Martin J Sevenoaks and Robert A Stockley Address Department of Medicine Queen Elizabeth Hospital Birmingham UK Email Martin J Sevenoaks - Robert A Stockley - Corresponding author Published 02 May 2006 Received 06 December 2005 Respiratory Research 2006 7 70 doi 1465-9921 -7-70 Accepted 02 May 2006 This article is available from http content 7 1 70 2006 Sevenoaks and Stockley licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Chronic Obstructive Pulmonary Disease COPD is and will remain a major cause of morbidity and mortality worldwide. The severity of airflow obstruction is known to relate to overall health status and mortality. However even allowing for common aetiological factors a link has been identified between COPD and other systemic diseases such as cardiovascular disease diabetes and osteoporosis. COPD is known to be an inflammatory condition and neutrophil elastase has long been considered a significant mediator of the disease. Pro-inflammatory cytokines in particular TNF-a Tumour Necrosis Factor alpha may be the driving force behind the disease process. However the roles of inflammation and these pro-inflammatory cytokines may extend beyond the lungs and play a part in the systemic effects of the disease and associated co-morbidities. This article describes the mechanisms involved and proposes a common inflammatory TNF-a phenotype that may in part account for the associations. Introduction Chronic Obstructive Pulmonary Disease COPD is and will remain a major cause .
