Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Angiogenesis in Interstitial Lung Diseases: a pathogenetic hallmark or a bystander. | Respiratory Research BioMed Central Open Access Review Angiogenesis in Interstitial Lung Diseases a pathogenetic hallmark or a bystander Argyris Tzouvelekis Stavros Anevlavis and Demosthenes Bouros Address Department of Pneumonology Medical School Democritus University of Thrace Greece Email Argyris Tzouvelekis - atzouvelekis@ Stavros Anevlavis - anevlavis@ Demosthenes Bouros - bouros@ Corresponding author Published 25 May 2006 Received 24 January 2006 Respiratory Research 2006 7 82 doi 1465-9921 -7-82 Accepted 25 May 2006 This article is available from http content 7 1 82 2006 Tzouvelekis et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The past ten years parallels have been drawn between the biology of cancer and pulmonary fibrosis. The unremitting recruitment and maintenance of the altered fibroblast phenotype with generation and proliferation of immortal myofibroblasts is reminiscent with the transformation of cancer cells. A hallmark of tumorigenesis is the production of new blood vessels to facilitate tumor growth and mediate organ-specific metastases. On the other hand several chronic fibroproliferative disorders including fibrotic lung diseases are associated with aberrant angiogenesis. Angiogenesis the process of new blood vessel formation is under strict regulation determined by a dual yet opposing balance of angiogenic and angiostatic factors that promote or inhibit neovascularization respectively. While numerous studies have examined so far the interplay between aberrant vascular and matrix remodeling the relative role of angiogenesis in the initiation and or progression of the fibrotic cascade still remains elusive and controversial. The
