Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Participation of the PI-3K/Akt-NF-κB signaling pathways in hypoxia-induced mitogenic factor-stimulated Flk-1 . | Respiratory Research BioMed Central Open Access Participation of the PI-3K Akt-NF-KB signaling pathways in hypoxia-induced mitogenic factor-stimulated Flk-1 expression in endothelial cells Qiangsong Tong 1 Liduan Zheng2 Li Lin3 Bo Li1 Danming Wang1 Chuanshu Huang4 George M Matuschak1 and Dechun Li 1 Address Department of Internal Medicine Saint Louis University Saint Louis MO 63110 USA 2Department of Pathology Union Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430022 China 3Department of Medicine Johns Hopkins University School of Medicine Baltimore MD 21287 USA and 4Nelson Institute of Environmental Medicine New York University School of Medicine Tuxedo NY 10987 USA Email QiangsongTong-qtong@ Liduan Zheng-ld_zheng@ Li Lin-linli@ Bo Li - Danming Wang - dwang@ Chuanshu Huang - changshu@ George M Matuschak - matuscgm@ Dechun Li - drdechunli@ Corresponding author Published 27 July 2006 Received 19 April 2006 Respiratory Research 2006 7 101 doi 1465-9921-7-101 Accepted 27 July 2006 This article is available from http content 7 1 101 2006 Tong et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Hypoxia-induced mitogenic factor HIMF a lung-specific growth factor promotes vascular tubule formation in a matrigel plug model. We initially found that HIMF enhances vascular endothelial growth factor VEGF expression in lung epithelial cells. In present work we tested whether HIMF modulates expression of fetal liver kinase-1 Flk-1 in endothelial cells and dissected the possible signaling pathways that link HIMF to Flk-1 upregulation. Methods .
