Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Inhalation of the Rho-kinase inhibitor Y-27632 reverses allergen-induced airway hyperresponsiveness after the early and late asthmatic reaction. | Respiratory Research BioMed Central Research Inhalation of the Rho-kinase inhibitor Y-27632 reverses allergen-induced airway hyperresponsiveness after the early and late asthmatic reaction Dedmer Schaafsma I Sophie T Bos Annet B Zuidhof Johan Zaagsma and Herman Meurs Open Access Address Department of Molecular Pharmacology University of Groningen Antonius Deusinglaan 1 9713 AV Groningen The Netherlands Email Dedmer Schaafsma - I Sophie T Bos - Annet B Johan Zaagsma - Herman Meurs - Corresponding author Published 26 September 2006 Received 13 July 2006 Accepted 26 September 2006 Respiratory Research 2006 7 121 doi 1465-9921-7-121 This article is available from http content 7 1 121 2006 Schaafsma et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In guinea pigs we have previously demonstrated that the contribution of Rho-kinase to airway responsiveness in vivo and ex vivo is enhanced after active sensitization with ovalbumin OA . Using conscious unrestrained OA-sensitized guina pigs we now investigated the role of Rho-kinase in the development of airway hyperresponsiveness AHR after the allergen-induced early EAR and late asthmatic reaction LAR in vivo. Methods Histamine and PGF2a PC100-values provocation concentrations causing 100 increase in pleural pressure were assessed before OA-challenge basal airway responsiveness and after the OA-induced EAR 5 h after challenge and LAR 23 h after challenge . Thirty minutes later saline or the specific Rho-kinase inhibitor Y-27632 5 mM nebulizer .
