Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Onset of relief of dyspnoea with budesonide/formoterol or salbutamol following methacholine-induced severe bronchoconstriction in adults with asthma: a double-blind, placebo-controlled study. | Respiratory Research BioMed Central Research Onset of relief of dyspnoea with budesonide formoterol or salbutamol following methacholine-induced severe bronchoconstriction in adults with asthma a double-blind placebo-controlled study René E Jonkers 1 Theo A Bantje2 and René Aalbers3 Open Access Address department of Pulmonary Diseases Academic Medical Centre Amsterdam The Netherlands department of Pulmonary Diseases Amphia Ziekenhuis Breda The Netherlands and department of Pulmonary Diseases Martini Hospital Groningen The Netherlands Email René E Jonkers - Theo A Bantje - TBantje@ René Aalbers - Corresponding author Published 04 December 2006 Received 29 June 2006 Accepted 04 December 2006 Respiratory Research 2006 7 141 doi 1465-9921-7-141 This article is available from http content 7 1 141 2006 Jonkers et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The long-acting P2-agonist LABA formoterol has an onset of effect comparable to that of salbutamol. Consequently the combination of formoterol and budesonide in one inhaler approved for maintenance use can potentially be used for reliever therapy. This study compared the onset of relief from induced bronchospasm with a single dose of budesonide formoterol versus standard salbutamol therapy in patients with asthma. Methods In this randomised double-blind placebo-controlled cross-over study 32 patients with asthma underwent a methacholine provocation test leading to a fall in forced expiratory volume in 1 second FEV of 30 at enrolment Visit 1 and three subsequent study visits Visits 2-4 . Immediately after each provocation at Visits 2-4 patients received one of three test
