Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Hypoxia and dehydroepiandrosterone in old age: a mouse survival study. | Respiratory Research BioMed Central Research Hypoxia and dehydroepiandrosterone in old age a mouse survival study Edouard H Debonneuil 1 Janine Quillard2 and Etienne-Emile Baulieu1 Open Access Address Unstitut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 788. Pincus Building 80 rue du Général Leclerc 94276 Le Kremlin-Bicêtre Cedex France and 2Service d Anatomo-Pathologie Hôpital de Bicêtre Assistance Publique-Hôpitaux de Paris Le Kremlin-Bicêtre France Email Edouard H Debonneuil - edebonneuil@ Janine Quillard - Etienne-Emile Baulieu - baulieu@ Corresponding author Published 18 December 2006 Received 12 May 2006 Accepted 18 December 2006 Respiratory Research 2006 7 144 doi l 465-9921-7-144 This article is available from http content 7 1 144 2006 Debonneuil et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Survival remains an issue in pulmonary hypertension a chronic disorder that often affects aged human adults. In young adult mice and rats chronic 50 hypoxia 11 FIO2 or atm induces pulmonary hypertension without threatening life. In this framework oral dehydroepiandrosterone was recently shown to prevent and reverse pulmonary hypertension in rats within a few weeks. To evaluate dehydroepiandrosterone therapy more globally in the long term and in old age we investigated whether hypoxia decreases lifespan and whether dehydroepiandrosterone improves survival under hypoxia. Methods 240 C57BL 6 mice were treated from the age of 2l months until death by normobaric hypoxia 11 FIO2 or normoxia both with and without .
