Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Open Access Following damage, the majority of bone marrow-derived airway cells express an epithelial marker. | Respiratory Research BioMed Central Research Following damage the majority of bone marrow-derived airway cells express an epithelial marker Heather MacPhersonh Pamela A KeiC Carol J Edwards Sheila Webb and Julia R Dorin Open Access Address MRC Human Genetics Unit Western General Hospital Crewe Road South Edinburgh EH4 2XU UK Email Heather MacPherson - Pamela A Keir - Carol J Edwards - Sheila Webb - Julia R Dorin - Corresponding author tEqual contributors Published 19 December 2006 Received 28 July 2006 Accepted 19 December 2006 Respiratory Research 2006 7 145 doi 1465-9921-7-145 This article is available from http content 7 1 145 2006 MacPherson et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Adult-derived bone marrow stem cells are capable of reconstituting the haematopoietic system. However there is ongoing debate in the literature as to whether bone marrow derived cells have the ability to populate other tissues and express tissue specific markers. The airway has been an organ of major interest and was one of the first where this was demonstrated. We have previously demonstrated that the mouse airway can be repopulated by side population bone marrow transplanted cells. Here we investigate the frequency and phenotypic nature of these bone marrow derived cells. Methods Female mice were engrafted with male whole bone marrow or side population SP cells and subjected to detergent-induced damage after 3 months. Donor cells were identified by Y chromosome
