Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Improved outcomes in patients with chronic obstructive pulmonary disease treated with salmeterol compared with placebo/usual therapy: results of a meta-analysis. | Respiratory Research BioMed Central Research Improved outcomes in patients with chronic obstructive pulmonary disease treated with salmeterol compared with placebo usual therapy results of a meta-analysis Robert A Stockley 1 Philip J Whitehead2 and Michael K Williams2 Open Access Address 1Queen Elizabeth Hospital Birmingham UK and 2GlaxoSmithKline Greenford Road Greenford Middlesex UB6 OHE UK Email Robert A Stockley - Philip J Whitehead - Michael K Williams - Corresponding author Published 29 December 2006 Respiratory Research 2006 7 147 doi 1465-9921-7-147 Received 14 November 2006 Accepted 29 December 2006 This article is available from http content 7 1 147 2006 Stockley et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Several studies have demonstrated that long-acting p2-agonists such as salmeterol are beneficial in chronic obstructive pulmonary disease COPD . A meta-analysis was therefore conducted to review studies in COPD to provide pooled estimates of the effect of salmeterol 50 mcg taken twice daily in addition to usual therapy on several clinically relevant endpoints when compared with placebo usual therapy. Methods An extensive search of literature and clinical trial databases was conducted using the terms salmeterol COPD chronic obstructive bronchitis and emphysema. Nine randomized double-blind parallel-group placebo-controlled trials of 12 week duration with salmeterol 50 mcg bid treatment in COPD were included 3500 patients with a further 14 trials excluded due to study design or reporting .
