Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí y học Molecular Biology cung cấp cho các bạn kiến thức về ngành sinh học đề tài: Distinguishing between hot-spots and melting-pots of genetic diversity using haplotype connectivity. | Nguyen et al. Algorithms for Molecular Biology 2010 5 19 http content 5 1 19 AMR ALGORITHMS FOR MOLECULAR BIOLOGY RESEARCH Open Access Distinguishing between hot-spots and melting-pots of genetic diversity using haplotype connectivity Binh Nguyen1 Andreas Spillner2 Brent C Emerson3 Vincent Moulton1 Abstract We introduce a method to help identify how the genetic diversity of a species within a geographic region might have arisen. This problem appears for example in the context of identifying refugia in phylogeography and in the conservation of biodiversity where it is a factor in nature reserve selection. Complementing current methods for measuring genetic diversity we analyze pairwise distances between the haplotypes of a species found in a geographic region and derive a quantity called haplotype connectivity that aims to capture how divergent the haplotypes are relative to one another. We propose using haplotype connectivity to indicate whether for geographic regions that harbor a highly diverse collection of haplotypes diversity evolved inside a region over a long period of time a hot-spot or is the result of a more recent mixture a melting-pot . We describe how the haplotype connectivity for a collection of haplotypes can be computed efficiently and briefly discuss some related optimization problems that arise in this context. We illustrate the applicability of our method using two previously published data sets of a species of beetle from the genus Brachyderes and a species of tree from the genus Pinus. Background It is now increasingly recognized that past climatic events have played a significant role in shaping the distribution of genetic diversity within species across the landscape. The distribution of this genetic diversity can leave signatures indicating the locations of refugia or hot-spots . regions in which species have persisted for long periods of time. These regions are important as they have contributed to much of the observed .
