Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Influence of atorvastatin on coronary calcifications and myocardial perfusion defects in systemic lupus erythematosus patients: a prospective, randomized, double-masked, placebo-controlled study. | Plazak et al. Arthritis Research Therapy 2011 13 R117 http content 13 4 R117 RESEARCH ARTICLE Open Access Influence of atorvastatin on coronary calcifications and myocardial perfusion defects in systemic lupus erythematosus patients a prospective randomized double-masked placebo-controlled study 1 21 1 3 Wojciech Plazak Krzysztof Gryga Hanna Dziedzic Lidia Tomkiewicz-Pajak Malgorzata Konieczynska Piotr Podolec1 and Jacek Musial2 Abstract Introduction Mortality in systemic lupus erythematosus SLE patients is influenced by an increased occurrence of severe cardiovascular complications. Statins have been proven to protect a wide spectrum of SLE patients from these complications. This study was conducted to determine the possible efficacy of atorvastatin in SLE patients as assessed by multi-detector computed tomography MDCT -based coronary calcium scoring and single photon emission computed tomography SPECT of the myocardium. Methods Sixty SLE patients in stable clinical conditions were randomized to receive either atorvastatin 40 mg daily n 28 or placebo n 32 . Clinical and biochemical evaluation together with MDCT-based coronary calcium scoring and SPECT studies Tc-99 m sestamibi were performed at the time of randomization and after 1 year of treatment. Results At randomization SPECT revealed perfusion defects at rest in 22 patients and exercise-induced defects in 8 whereas MDCT revealed coronary calcifications in 15 subjects 25 . Coronary calcium deposits increased after 1 year in the placebo group plaque volume change from to P calcium score from to P but not in the atorvastatin group plaque volume vs. P not significant calcium score vs. P not significant . The atorvastatin group showed a decrease in total serum cholesterol from to mmol L P LDL cholesterol to mmol L P triglycerides to .
