Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Green tea: a new option for the prevention or control of osteoarthritis. | Katiyar and Raman Arthritis Research Therapy 2011 13 121 http content 13 4 121 EDITORIAL L_ Green tea a new option for the prevention or control of osteoarthritis Santosh K Katiyar1 2 and Chander Raman3 See related research by Akhtar and Haqqi http content 13 3 R93 Abstract IL-ip is a major cytokine driving the inflammatory processes leading to the pathophysiology of osteoarthritis and other inflammatory diseases. Blockade of IL-ip activity using substances such as the naturally occurring IL-1 receptor antagonist or anti-IL-ip monoclonal antibody are currently being used or tested as therapy. However such treatments are ineffective in osteoarthritis. In a recent study epigallocatechin-3-gallate a green tea polyphenol was found to be effective in reducing IL-ip-induced inflammatory cytokines TNFa IL-6 granulocytemacrophage colony-stimulating factor and several chemokines from human chondrocytes. The use of green tea polyphenols may be beneficial as a therapeutic addition to biologics that control IL-ip activity by increasing effectiveness and or reducing dosage. Inflammation plays a key role in osteoarthritis OA . The overexpression of cyclooxygenase-2 and proinflammatory cytokines has been reported to contribute to the development of OA. Since chronic inflammation is the leading cause of connective tissue remodeling and destruction in OA an approach that decreases inflammation may facilitate the development of an effective strategy for its treatment and or prevention. The use of some drugs has demonstrated potential in treatment of OA but longterm safety resistance and toxicity concerns have hindered their long-term acceptance as viable clinical chemopreventive agents. The exploration of new agents particularly dietary with low toxicity that can target inflammatory responses should form the basis for Correspondence skatiyar@ department of Dermatology University of Alabama at Birmingham Birmingham AL .
