Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Characterization of a novel and spontaneous mouse model of inflammatory arthritis. | Cuzzocrea Arthritis Research Therapy 2011 13 126 http content 13 5 126 EDITORIAL L_ Characterization of a novel and spontaneous mouse model of inflammatory arthritis Salvatore Cuzzocrea Abstract Arthritis is a heterogeneous disease comprising a group of inflammatory and non-inflammatory conditions that can cause pain stiffness and swelling in the joints. Mouse models of rheumatoid arthritis RA have been critical for identifying genetic and cellular mechanisms of RA and several new mouse models have been produced. Various methods have been applied to induce experimental models of arthritis in animals that would provide important insights into the etiopathogenetic mechanisms of human RA. Adipue and colleagues recently discovered that mice in their breeding colony spontaneously developed inflamed joints reminiscent of RA and may therefore have found a new model to examine pathogenic mechanisms and test new treatments for this human inflammatory disease. Mouse model of rheumatoid arthritis Adipue and colleagues 1 have characterized the novel IIJ inherited inflamed joints mouse strain a new murine model of inflammatory possibly autoimmune arthritis that is similar both histologically and serologically to human rheumatoid arthritis RA and other murine models of autoimmune arthritis 1 . RA is a chronic and progressive inflammatory disorder characterized by synovitis and severe joint destruction. The pathogenesis of RA is a complex process involving synovial cell proliferation and fibrosis pannus formation and cartilage and bone erosion 2 . Rodent models of RA have been used extensively to evaluate potential new therapeutic agents. Arthritis in the mouse can be induced can occur spontaneously in some inbred strains or can result from single gene mutations Table 1 . Induced murine arthritis Correspondence salvator@. Department of Clinical and Experimental Medicine and Pharmacology School of Medicine University of Messina Torre .
