Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis. | Research paper 11 Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis Paul M Steinwald Kevin T Whang Kenneth L Becker Richard H Snider Eric S Nylen and Jon C White Background Increased serum levels of procalcitonin ProCT and its component peptides have been reported in humans with sepsis. Using a hamster model of bacterial peritonitis we investigated whether serum ProCT levels are elevated and correlate with mortality and hypocalcemia. Results Incremental increases in doses of bacteria resulted in proportional increases in 72 h mortality rates 0 20 70 and 100 as well as increases in serum total immunoreactive calcitonin iCT levels at 12 h 250 380 1960 and 4020 pg ml respectively vs control levels of 21 pg ml . Gel filtration studies revealed that ProCT was the predominant 90 molecular form of serum iCT secreted. In the metabolic experiments total iCT peaked at 12 h concurrent with the maximal decrease in serum calcium. Conclusions In this animal model hyper-procalcitoninemia was an early systemic marker of sepsis which correlated closely with mortality and had an inverse correlation with serum calcium levels. Addresses Department of Surgery Veterans Affairs Medical Center and George Washington University Medical Center 2150 Pennsylvania Avenue Nw Washington DC 20037 UsA. Department of Surgery Veterans Affairs Medical Center and Georgetown University Medical Center 3800 Reservoir Road NW Washington DC USA. Section of Endocrinology Veterans Affairs Medical Center and George Washington University Medical Center 50 Irving Street NW Washington DC 20422 USA. Correspondence Jon C White MD Department of Surgery Veterans Affairs Medical Center and George Washington University Medical Center 50 Irving Street nW Washington DC 20422 USA Email jcwhite1@ Keywords inflammation peritonitis procalcitonin prohormone serum marker Received 12 August 1997 Revisions requested 6 October 1997 Revisions received 3 February 1998 Accepted 24 .
