Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Cisapride decreases gastric content aspiration in mechanically ventilated patients. | Research paper 39 Cisapride decreases gastric content aspiration in mechanically ventilated patients John Pneumatikos Basil Koulouras Christ Frangides Dian Goe and George Nakos Objective To determine the effect of the prokinetic agent cisapride in the prevention of aspiration of gastric contents. Design A prospective randomized two-period crossover study. Setting Fourteen-bed polyvalent intensive care unit in a University Hospital. Patients Eighteen intubated mechanically ventilated patients who were seated in a semirecumbent position were studied. Method Tc-99m sulfur colloid 80 megabecquerels was administered via nasogastric tube on 2 consecutive days. Patients randomly received cisapride 10 mg via nasogastric tube one day and a placebo the other. Bronchial secretions were obtained before and for 5 consecutive h after Tc-99m administration. The radioactivity was measured in a standard amount 1 ml of bronchial fluid using a gamma counter and expressed as counts per min cpm after correction for decay. Results Sixteen out of 18 88 patients had increased radioactivity in bronchial secretions. The radioactivity increased over time both with and without cisapride although it was lower in patients receiving cisapride than in those receiving a placebo. The cumulative bronchial secretion radioactivity obtained when patients received cisapride was significantly lower than when patients received a placebo 7540 5330 and 21965 16080 cpm respectively P . Address Intensive Care Unit University Hospital of Ioannina Greece. Correspondence George Nakos MD FCCP Intensive Care Unit University Hospital of Ioannina University Street 45500 Ioannina Greece. Tel 30 651 99353 fax 30 651 46618 e-mail gnakos@ Keywords cisapride mechanical ventilation aspiration pneumonia VAP Received 25 February 1998 Revisions requested 24 April 1998 Revisions received 28 May 1998 Accepted 16 February 1999 Published 16 March 1999 Crit Care 1999 3 39-43 The original version of this paper is
