Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Comparison of procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations at different SOFA scores during the course of sepsis and MODS. | Research paper 45 Comparison of procalcitonin PCT and C-reactive protein CRP plasma concentrations at different SOFA scores during the course of sepsis and MODS Michael Meisner Klaus Tschaikowsky Thomas Palmaers and Joachim Schmidt Objectives The relation of procalcitonin PCT plasma concentrations compared with C-reactive protein CRP was analyzed in patients with different severity of multiple organ dysfunction syndrome MODS and systemic inflammation. Patients and methods PCT CRP the sepsis-related organ failure assessment SOFA score the Acute Physiology Age Chronic Health Evaluation APACHE II score and survival were evaluated in 40 patients with systemic inflammation and consecutive MODS over a period of 15 days. Results Higher SOFA score levels were associated with significantly higher PCT plasma concentrations SOFA 7-12 PCT ng ml Sofa 19-24 PCT ng ml median whereas CRP was elevated irrespective of the scores observed SOFT 7-12 CRP 131 mg l SOFT 19-24 CrP 135 mg l . PCT of non-surviving patients was initially not different from that of survivors but significantly increased after the fourth day following onset of the disease whereas CRP was not different between both groups throughout the whole observation period. Conclusions Measurement of PCT concentrations during multiple organ dysfunction syndrome provides more information about the severity and the course of the disease than that of CRP. Regarding the strong association of PCT and the respective score systems in future studies we recommend evaluation also of the severity of inflammation and MODS when PCT concentrations were compared between different types of disease. Address Department of Anaesthesiology University of Erlangen-Nuremburg Krankenhausstr. 12 D-91054 Erlangan Germany. Correspondence Dr med Meisner Department of Anesthesiology University of Jena Bachstr. 18 D-07743 Jena. Tel 49 3641 933041 e-mail meisner@ Keywords SOFA CRP MODS procalcitonin PCT sepsis Received 28
