Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Sub-chronic inhalation of high concentrations of manganese sulfate induces lower airway pathology in rhesus monkeys. | Respiratory Research BioMed Central Research Open Access Sub-chronic inhalation of high concentrations of manganese sulfate induces lower airway pathology in rhesus monkeys David C Dorman 1 Melanie F Struve1 Elizabeth A Gross1 Brian A Wong1 and Paul C Howroyd2 Address 1CIIT Centers for Health Research 6 Davis Drive . Box 12137 Research Triangle Park NC 27709-2137 USA and - Experimental Pathology Laboratories Inc. . Box 12766 Research Triangle Park NC 27709 USA Email David C Dorman - dorman@ Melanie F Struve - struve@ Elizabeth A Gross - gross@ Brian A Wong - wong@ Paul C Howroyd - Corresponding author Published 21 October 2005 Received 30 March 2005 Respiratory Research 2005 6 121 doi 1465-9921-6-121 Accepted 21 October 2005 This article is available from http content 6 1 121 2005 Dorman et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Neurotoxicity and pulmonary dysfunction are well-recognized problems associated with prolonged human exposure to high concentrations of airborne manganese. Surprisingly histological characterization of pulmonary responses induced by manganese remains incomplete. The primary objective of this study was to characterize histologic changes in the monkey respiratory tract following manganese inhalation. Methods Subchronic 6 hr day 5 days week inhalation exposure of young male rhesus monkeys to manganese sulfate was performed. One cohort of monkeys n 4-6 animals exposure concentration was exposed to air or manganese sulfate at or mg Mn m3 for 65 exposure days. Another eight monkeys were exposed to manganese sulfate at mg Mn m3 for 65 exposure days and held for 45 or
