Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Characterization of lymphocyte populations in nonspecific. | Respiratory Research BioMed Central Research Characterization of lymphocyte populations in nonspecific interstitial pneumonia Karina A Keogh and Andrew H Limper Open Access Address Thoracic Diseases Research Unit Division of Pulmonary Critical Care Medicine Department of Internal Medicine Mayo Clinic College of Medicine Rochester. MN 55905 USA Email Karina A Keogh - Andrew H Limper - Corresponding author Published 15 November 2005 Received II March 2005 Accepted 15 November 2005 Respiratory Research 2005 6 137 doi 1465-9921-6-1 37 This article is available from http content 6 1 137 2005 Keogh and Limper licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Study objectives Nonspecific interstitial pneumonia NSIP has been identified as a distinct entity with a more favorable prognosis and better response to immunosuppressive therapies than usual interstitial pneumonia UIP . However the inflammatory profile of NSIP has not been characterized. Design Using immunohistochemistry techniques on open lung biopsy specimens the infiltrate in NSIP was characterized in terms of T and B cells and macrophages and the T cell population further identified as either CD4 helper or CD8 suppressor-cytotoxic T cells. The extent of Th1 and Th2 cytokine producing cells was determined and compared to specimens from patients with UIP. Results In ten NSIP tissue samples 4 of mononuclear cells expressed CD3 CD4 2 CD8 CD20 and had CD68 expression. Mononuclear cells expressed INFy of the time and IL-4 in 1 . In contrast biopsies from eight patients with UIP demonstrated substantially less cellular staining for either .
