Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy. | Respiratory Research BioMed Central Research Open Access Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy Joseph Donfack11 Daniel H Schneider11 Zheng Tan1 Thorsten Kurz1 Inna Dubchak3 Kelly A Frazer2 and Carole Ober 1 Address Department of Human Genetics 920 E. 58th Street The University of Chicago Chicago IL 60637 USA 2Perlegen Sciences Mountain View CA 94043 USA and 3Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Email Joseph Donfack - jdonfack@ Daniel H Schneider - dschneid@ Zheng Tan - tzheng@ Thorsten Kurz - eine_mail@ Inna Dubchak - ildubchak@ Kelly A Frazer - Kelly_Frazer@ Carole Ober - c-ober@ Corresponding author fEqual contributors Published 10 December 2005 Received 10 September 2005 Accepted 10 December 2005 Respiratory Research 2005 6 145 doi 86 1465-9921-6-145 This article is available from http content 6 1 145 2005 Donfack et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Evolutionary conserved sequences likely have biological function. Methods To determine whether variation in conserved sequences in non-coding DNA contributes to risk for human disease we studied six conserved non-coding elements in the Th2 cytokine cluster on human chromosome 5q31 in a large Hutterite pedigree and in samples of outbred European American and African American asthma cases and controls. Results Among six conserved non-coding elements 100 bp 70 identity human-mouse comparison we identified one single nucleotide polymorphism SNP in each of two conserved elements and six SNPs in the flanking regions of three
