Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Antenatal infection/inflammation and postnatal lung maturation and injury. | Available online http content 2 1 027 Review Antenatal infection inflammation and postnatal lung maturation and injury Alan H Jobe and Machiko Ikegami Children s Hospital Medical Center Cincinnati Ohio USA Correspondence Alan H Jobe MD PhD 3333 Burnet Avenue Cincinnati OH 45229-3039 USA. Tel 1 513 636 8563 fax 1 513 636 8691 e-mail jobea0@ Received 6 November 2000 Accepted 13 December 2000 Published 11 January 2001 Respir Res 2001 2 27-32 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Chorioamnionitis is frequently associated with preterm deliveries before 30 weeks gestation. Chorioamnionitis correlates both with an increased risk of bronchopulmonary dysplasia and with a decreased risk of respiratory distress syndrome. Both interleukin-1a and endotoxin can induce inflammation in the fetal lungs and lung maturation after preterm birth when given by intra-amniotic injection. Inflammation can also result in an arrest of alveolarization and this lung developmental abnormality is prominent in the lungs of preterm infants that die of bronchopulmonary dysplasia. The mechanisms by which infection inflammation can have both beneficial and injurious effects on the preterm lung remain to be characterized. Keywords alveolarization amnionitis bronchopulmonary dysplasia cytokines respiratory distress syndrome Introduction Recent information supports the concept that infection inflammation resulting in preterm delivery can promote both early lung maturation and lung injury. As Fig. 1 illustrates the lung continues to develop after preterm birth. The human lung undergoes a transition from the canalicular stage to the saccular stage of development at about 22 weeks and alveolarization by secondary septal formation does not begin until about 30-32 weeks gestation 1 . Therefore both clinical events in fetal life before preterm birth at 26 weeks gestation 65 of gestation and preterm birth itself have the potential to .
