Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists. | Available online http content 2 2 066 Review Th2 cytokines and asthma Interleukin-4 its role in the pathogenesis of asthma and targeting it for asthma treatment with interleukin-4 receptor antagonists John W Steinke and Larry Borish University of Virginia Charlottesville Virginia USA Correspondence Larry Borish MD Asthma and Allergic Disease Center Box 801355 University of Virginia Health Systems Charlottesville VA 22908 USA. Tel 1 804 924 5917 fax 1 804 924 5779 e-mail lb4m@ Received 6 December 2000 Accepted 8 January 2001 Published 19 February 2001 Respir Res 2001 2 66-70 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Interleukin-4 IL-4 mediates important pro-inflammatory functions in asthma including induction of the IgE isotype switch expression of vascular cell adhesion molecule-1 VCAM-1 promotion of eosinophil transmigration across endothelium mucus secretion and differentiation of T helper type 2 lymphocytes leading to cytokine release. Asthma is a complex genetic disorder that has been linked to polymorphisms in the IL-4 gene promoter and proteins involved in IL-4 signaling. Soluble recombinant IL-4 receptor lacks transmembrane and cytoplasmic activating domains and can therefore sequester IL-4 without mediating cellular activation. We report the results of initial clinical trials which demonstrate clinical efficacy of this naturally occurring IL-4 antagonist as a therapeutic agent in asthma. Keywords asthma genetics soluble recombinant human interleukin-4 receptor T helper lymphocytes Introduction Interleukin IL -4 is a key cytokine in the development of allergic inflammation. It is associated with induction of the isotype switch and secretion of IgE by B lymphocytes 1 . IgE-mediated immune responses are further enhanced by IL-4 through its ability to upregulate IgE receptors on the cell surface the low-affinity IgE receptor Fc RII CD23 on B lymphocytes and mononuclear phagocytic cells and .
