Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Role of epidermal growth factor receptor activation in regulating mucin synthesis. | Available online http content 2 2 085 Review Role of epidermal growth factor receptor activation in regulating mucin synthesis Jay A Nadel Cardiovascular Research Institute Departments of Medicine and Physiology University of California San Francisco California USA Correspondence Jay A Nadel MD University of California San Francisco 505 Parnassus Room M-1325 - Box 0130 Cardiovascular Research Institute San Francisco CA 94143-0130 USA. Tel 1 415 476 1105 fax 1 415 476 2283 e-mail janadel@ Received 10 January 2001 Accepted 2 February 2001 Published 21 February 2001 Respir Res 2001 2 85-89 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Healthy individuals have few goblet cells in their airways but in patients with hypersecretory diseases goblet-cell upregulation results in mucus hypersecretion airway plugging and death. Multiple stimuli produce hypersecretion via epidermal growth factor receptor EGFR expression and activation causing goblet-cell metaplasia from Clara cells by a process of cell differentiation. These cells are also believed to be the cells of origin of non-small-cell lung cancer but this occurs via cell multiplication. The mechanisms that determine which pathway is chosen are critical but largely unknown. Although no effective therapy exists for hypersecretion at present the EGFR cascade suggests methods for effective therapeutic intervention. Keywords activated neutrophils airway goblet cell asthma chronic intubation cigarette smoke nasal polyp oxygen free radical tumor necrosis factor-a Introduction Epidermal growth factor EGF was discovered by Cohen and he and his colleagues subsequently extended our knowledge of the mechanisms of action of EGF and its receptor EGFR 1 . EGFR is a 170kDa membrane glycoprotein which is activated by ligands such as EGF transforming growth factor TGF -a heparin-binding EGF amphiregulin betacellulin and epiregulin. These proteins are synthesized as .
