Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Role of endothelin-1 in lung disease. | Available online http content 2 2 090 Review Role of endothelin-1 in lung disease Karen A Fagan Ivan F McMurtry and David M Rodman Cardiovascular Pulmonary Research Laboratory Division of Pulmonary Sciences and Critical Care Medicine University of Colorado Health Sciences Center Denver Colorado USA Correspondence Karen A Fagan MD Assistant Professor of Medicine Division of Pulmonary Sciences and Critical Care Medicine University of Colorado Health Sciences Center 4200 East Ninth Avenue B-133 Denver CO 80262 USA. Tel 1 303 315 1305 fax 1 303 315 4871 e-mail Received 15 December 2000 Accepted 8 January 2001 Published 22 February 2001 Respir Res 2001 2 90-101 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Endothelin-1 ET-1 is a 21 amino acid peptide with diverse biological activity that has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of smooth muscle tone and inflammatory mediator that may play a key role in diseases of the airways pulmonary circulation and inflammatory lung diseases both acute and chronic. This review will focus on the biology of ET-1 and its role in lung disease. Keywords asthma endothelin fibrosis inflammation pulmonary hypertension Introduction ET-1 ET-2 and ET-3 are members of a peptide family that has been the subject of much interest in the past decade. Our laboratory and that of Highsmith identified this peptide vasoconstrictor secreted from endothelial cells 1-3 that was subsequently isolated sequenced cloned and named by Yanagisawa in 1988 4 . The many diverse and overlapping functions of these peptides have since implicated endothelins in both homeostatic mechanisms as well as diseases of the lungs. This review will focus on the role of endothelins particularly ET-1 emphasizing the need to better understand endothelin biology and function in a wide variety of disorders including diseases of the airways and pulmonary vasculature lung .
